Building blocks by functions Carboxylic acids Aldehydes Alkyl Halides Aryl Halides Boronic acids and their derivatives Primary Amines Secondary Amines Sulfonyl Chlorides/Fluorides Azides for “Click Chemistry” Other classes of building blocks: Acetylenes Acyl Halides Alcohols Alkenes Amides Amidines Amino Acids Azides Diamines Epoxides Halocarbamates Halocarbonates Halooximes Hydrazides Hydrazines Hydrazones Hydroxylamines Isocyanates Isothiocyanates Ketones Nitriles Oximes Sulfonamides Thioles For Library Synthesis DEL-compatible scaffolds MedChem Highlights Fluoroalkyl ethers for Drug Design N-Nitrosamines N-Trifluoromethyl Azoles for Drug Discovery Cyclic sulfates and sulfamidates as alkylating reagents Saturated Bioisosteres for ortho-substituted Benzenes other