Building Blocks Catalog

284 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

36B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from May 2023

Recent News

  • 22 May 2023   Press Releases

    Enamine Launches a New Chemistry Site in Germany

    Welcome to the latest update from Enamine - we're delighted to share our growth story with you. In our continued pursuit of scientific excellence and global expansion, we've launched a new subsidiary, Enamine Germany GmbH, based in Frankfurt's Höchst Industrial Park. This significant development strengthens our commitment to provide more localized and efficient services in organic synthesis and medicinal chemistry.

  • 27 April 2023   Press Releases

    Nostrum Biodiscovery and ENAMINE Join Forces to Develop a ...

    Barcelona, Spain, and Kyiv, Ukraine, April 27, 2023. Nostrum Biodiscovery, a leading provider of computational drug discovery services, and ENAMINE, a global supplier of chemical building blocks and screening compounds, announced today a groundbreaking collaboration for the co-development of a revolutionary search engine tailored for the REAL Space billion database. This partnership aims to deliver unparalleled performance in searching vast chemical spaces while utilizing low computational resources, thus increasing the efficiency and accessibility of drug discovery efforts.

    The collaboration will also focus on enhancing High Throughput Virtual Screening (HTVS) services to streamline the drug discovery process. Nostrum Biodiscovery's state-of-the-art AI-enabled screening platform will take center stage in this effort, boasting the capability to evaluate the entire billion compound collection in just hours. This innovative technology promises to identify potential drug candidates within weeks, significantly accelerating the discovery pipeline.

    ENAMINE’s expertise in the rapid and reliable provision of compounds will further strengthen the collaboration, ensuring that researchers have timely access to the vast array of molecules in the REAL Space database. This partnership will facilitate the seamless integration of Nostrum Biodiscovery's computational prowess with ENAMINE’s extensive compound collection, directly impacting companies interested in using services offered by both partners and ultimately benefiting the global scientific community and accelerating the path to new drug discoveries.

    [Victor Guallar, CSO Nostrum Biodiscovery] “We see it every day in our projects, using the REAL Space database with our AI/MM hybrid HTVS platform is a game changer in finding molecules. Our joint venture with ENAMINE demonstrates our commitment to integrating cutting-edge technology and high-quality compound collections to provide the pharmaceutical industry with unparalleled access to resources that expedite drug discovery. We believe that this partnership will serve as a catalyst for innovation, inspiring ventures to explore uncharted territories in the quest for novel therapeutics.”

    [Andrey Tarnovskiy, Sales Director, Europe at Enamine] “This year the size of Enamine’s REAL Space has reached tremendous 36 Billion compounds. We are excited to cooperate with Nostrum Biodiscovery to complement the available suite of search tools for REAL Space exploration with brand-new AI-based solution for high-throughput virtual screening and hope that our synergy will allow to facilitate and strengthen the drug discovery efforts of our customers.”

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  • 19 April 2023   Press Releases

    Enamine and Endogena Therapeutics – a Successful, Multi-Year Drug ...

    Kyiv, Ukraine, April 19, 2023 - Enamine Ltd., a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments, and screening compounds, gave an update of its long-standing research collaboration with Endogena Therapeutics AG, a clinicalstage biotech company focused on the development of endogenous regenerative medicines.

    Enamine provides Endogena with its integrated capability in medicinal chemistry to support Endogena’s small molecule drug discovery programs in the fields of hit finding, hit-to-lead and lead optimization.

    The companies have been collaborating under a Full Time Equivalent (FTE) model since 2019. The two discovery partners have been continuing their research collaboration to date, their research relationship not being impacted by the war in Ukraine. This collaboration extension, along with many others and new ones established by Enamine since February 24, 2022, already under the conflict, is a systematic positive trend experienced by the company, that demonstrates the support of its customers and the trust they have in receiving high-quality service backed up by the unparalleled number of diverse building blocks available at Enamine.

    Sven Weiler, Vice President of Medicinal Chemistry at Endogena, commented: “The interaction with colleagues from Enamine has been a smooth one from the start. In addition to the FTE model, it is great to have access to their huge compound collection and be able to flexibly use Enamine’s capacity to its full potential. We value the output and responsiveness of the Enamine team, helping us to achieve our demanding milestones. It is stunning to see how well Enamine has been able to keep pace after February 2022.”

    Michael Bossert, Head of Strategic Alliances at Enamine, added: “After 13 months of the war in the country, we are especially pleased to announce our collaboration with Endogena, a longlasting partner we have been serving during those several years with extensive medicinal chemistry and SAR efforts”.

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Enamine Ltd was founded in 1991 with the advent of high throughput screening in early drug discovery. The driving force of the company’s development was rapidly increasing demand for new chemical compounds. In over 15 years Enamine has become a global provider of Screening Compounds, Building Blocks, and Fragments for supporting a wide range of research programs conducted by pharmaceutical and biotech companies, drug discovery centers, academic institutions and other research organizations worldwide.

Over the years, the company has developed a comprehensiveset of R&D services to meet the ever increasing needs of the customers. Enamine supports complex medicinal chemistry programs offering the following chemical services: custom synthesis, compound library design, hit follow up support, support for lead optimization.

To complement chemical services, Enamine is investing heavily in expanding its biology services, which now include a wide range of reliable bioanalytical services, molecular screening programs and other biological studies.

The company is committed to providing Life Science industries with a one-stop-shop solution for a wide spectrum of research needs. In order to deliver on this ambitious statement, the company is constantly expanding its team of highly skilled chemists, biologists, and engineers, which now is above 500 people.

The Enamine headquarters occupy the space of 5 acres in Kyiv, Ukraine with multiple buildings for chemical and analytical labs, compound stock facilities, operations and business departments. The company has several stock facilities in the USA and Europe and it works through authorized representatives in Asian region.

  • 2-Oxabicyclo[2.2.2]octane: A New Bioisostere of the Phenyl Ring

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  • Novel Class of Piperidine Bioisosteres

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  • Synthesis of 3-Azabicyclo[3.1.1]heptanes

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  • CF3-Diazirines for photoaffinity labeling

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  • Practical scalable synthesis of N-CF3 substituted heterocycles

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  • Unexpected isomerization of oxetane carboxylic acids

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  • Deoxofluorination of Aliphatic and (Hetero)aromatic Acids

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  • Convenient Access to Conformationally Rigid Sultams

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  • Cobalt-containing conducting polymers on carboneous supports for catalytic hydrogenation of quinoline

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  • Cu-Catalyzed Pyridine Annulation via Oxidative Reaction of Cyclic Ketones with Propargyl Amine

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  • Expanding of the scope of Castagnoli–Cushman reaction: Anhydrides of cyclic 1,2-dicarbonic acids

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  • Expanding of the scope of Castagnoli–Cushman Reaction: trifluoracetaldehyde monohydrate

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  • G3 and G4 Buchwald Precatalysts: Scale up, QC and application for the semi-automated parallel synthesis

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  • Isoxazole and 1,2,4-Oxadiazole-Derived Phosphonates via [3+2] Cycloaddition

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  • 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrazine: Lead-oriented scaffold with three diversity points

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  • Synthesis and reactivity of N-difluoro-cyclopropyl-substituted pyrazoles

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  • Quick evaluation of catalytic activity of hydrogenation cata-lysts by UV spectra using imidazo[1,5-a]pyridines as probes

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  • Recent Advances in Difluorocyclopropanation of alkenes using Ruppert–Prakash reagent

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  • Selective Methylation of α-Methylene Ketones

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  • Straightforward Synthesis of All Isomeric (Cyclo, fluoro)alkylpiperidines

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  • Synthesis and properties of monoalkylsubstituted difluorocyclopropenes

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  • Synthesis of gem-difluorocycloheptanes building blocks

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  • Difluoro-substituted bicyclo[1.1.1]pentanes (BCPs) for medicinal chemistry

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  • Novel spirocyclic and fused cyclopropane scaffolds for medicinal chemistry

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  • Piperazine Bioisosteres for Drug Design

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  • New Covalent Fragment Libraries by parallel synthesis

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  • P(O)Me2-containing Building Blocks for Drug Design

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  • Unexpected macrocycles formation in a synthesis of fused aza-cycloalkyl oxazoles

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  • One-step Synthesis of Functionalized Pyridines by Reaction of Propargylamine and Ketones Catalyzed by Cu(II) Compounds

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  • Evolution of commercially available compounds for HTS

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  • Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

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  • Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

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  • Catalytic Hydrogenation of Quinoline on Composites of Graphene-like Carbon and 3Dmetals or Their Oxides

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  • New frontiers in Castagnoli–Cushman Reaction

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  • An Efficient Approach To Novel Tetrahydropyridoazepines. Expansion Of Azepines’ Drug-like Chemical Space

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  • Synthesis of Gem-difluorocyclobutane/pentane/hexane Building Blocks – Useful Reagent For Drug Discovery

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  • Ruppert – Prakash reagent as a difluorocarbene synthetic equivalent for the synthesis of medchem-relevant building blocks

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  • Cyclobutane ring as a conformational restriction tool

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  • Saturated Bioisosteres of Benzene with Improved Solubility

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  • Cubanes for Drug Design

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  • CH-Activation of L-Proline analogues

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  • Application of AI to REAL Space: A Step Ahead to Expand the Synthetically Feasible Chemical Space

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  • Conformationally-rigid pyrrolidines with improved water solubility

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  • Aminosulfonyl fluorides for drug design

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  • Difluorocyclopropanes for drug discovery

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  • Novel spirocycles for drug discovery

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  • Bicyclic amines for drug discovery by [2+2]-photocyclization

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  • 1,3-Oxazoles and 1,2,4-oxadiazoles as selective agonists of GPR40 receptor

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  • Design and synthesis of novel 3D-shaped building blocks to “Escape the Flatland”

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  • Proline analogues: advanced building blocks for drug design

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  • New synthetic approach to diverse heterocyclic sulfonyl chlorides

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  • Conformationally restricted scaffolds by Double-Mannich reaction of cyclic ketones

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  • Synthesis of unique pyrrolidines for drug discovery

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  • Design and synthesis of morpholine analogues

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  • Novel fluorinated amines for drug discovery

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  • CF 3CHN 2and C 2F 5CHN 2: highly underestimated reagents

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