Building Blocks Catalog

284 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

36B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from May 2023

Recent News

  • 22 May 2023   Press Releases

    Enamine Launches a New Chemistry Site in Germany

    Welcome to the latest update from Enamine - we're delighted to share our growth story with you. In our continued pursuit of scientific excellence and global expansion, we've launched a new subsidiary, Enamine Germany GmbH, based in Frankfurt's Höchst Industrial Park. This significant development strengthens our commitment to provide more localized and efficient services in organic synthesis and medicinal chemistry.

  • 27 April 2023   Press Releases

    Nostrum Biodiscovery and ENAMINE Join Forces to Develop a ...

    Barcelona, Spain, and Kyiv, Ukraine, April 27, 2023. Nostrum Biodiscovery, a leading provider of computational drug discovery services, and ENAMINE, a global supplier of chemical building blocks and screening compounds, announced today a groundbreaking collaboration for the co-development of a revolutionary search engine tailored for the REAL Space billion database. This partnership aims to deliver unparalleled performance in searching vast chemical spaces while utilizing low computational resources, thus increasing the efficiency and accessibility of drug discovery efforts.

    The collaboration will also focus on enhancing High Throughput Virtual Screening (HTVS) services to streamline the drug discovery process. Nostrum Biodiscovery's state-of-the-art AI-enabled screening platform will take center stage in this effort, boasting the capability to evaluate the entire billion compound collection in just hours. This innovative technology promises to identify potential drug candidates within weeks, significantly accelerating the discovery pipeline.

    ENAMINE’s expertise in the rapid and reliable provision of compounds will further strengthen the collaboration, ensuring that researchers have timely access to the vast array of molecules in the REAL Space database. This partnership will facilitate the seamless integration of Nostrum Biodiscovery's computational prowess with ENAMINE’s extensive compound collection, directly impacting companies interested in using services offered by both partners and ultimately benefiting the global scientific community and accelerating the path to new drug discoveries.

    [Victor Guallar, CSO Nostrum Biodiscovery] “We see it every day in our projects, using the REAL Space database with our AI/MM hybrid HTVS platform is a game changer in finding molecules. Our joint venture with ENAMINE demonstrates our commitment to integrating cutting-edge technology and high-quality compound collections to provide the pharmaceutical industry with unparalleled access to resources that expedite drug discovery. We believe that this partnership will serve as a catalyst for innovation, inspiring ventures to explore uncharted territories in the quest for novel therapeutics.”

    [Andrey Tarnovskiy, Sales Director, Europe at Enamine] “This year the size of Enamine’s REAL Space has reached tremendous 36 Billion compounds. We are excited to cooperate with Nostrum Biodiscovery to complement the available suite of search tools for REAL Space exploration with brand-new AI-based solution for high-throughput virtual screening and hope that our synergy will allow to facilitate and strengthen the drug discovery efforts of our customers.”

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  • 19 April 2023   Press Releases

    Enamine and Endogena Therapeutics – a Successful, Multi-Year Drug ...

    Kyiv, Ukraine, April 19, 2023 - Enamine Ltd., a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments, and screening compounds, gave an update of its long-standing research collaboration with Endogena Therapeutics AG, a clinicalstage biotech company focused on the development of endogenous regenerative medicines.

    Enamine provides Endogena with its integrated capability in medicinal chemistry to support Endogena’s small molecule drug discovery programs in the fields of hit finding, hit-to-lead and lead optimization.

    The companies have been collaborating under a Full Time Equivalent (FTE) model since 2019. The two discovery partners have been continuing their research collaboration to date, their research relationship not being impacted by the war in Ukraine. This collaboration extension, along with many others and new ones established by Enamine since February 24, 2022, already under the conflict, is a systematic positive trend experienced by the company, that demonstrates the support of its customers and the trust they have in receiving high-quality service backed up by the unparalleled number of diverse building blocks available at Enamine.

    Sven Weiler, Vice President of Medicinal Chemistry at Endogena, commented: “The interaction with colleagues from Enamine has been a smooth one from the start. In addition to the FTE model, it is great to have access to their huge compound collection and be able to flexibly use Enamine’s capacity to its full potential. We value the output and responsiveness of the Enamine team, helping us to achieve our demanding milestones. It is stunning to see how well Enamine has been able to keep pace after February 2022.”

    Michael Bossert, Head of Strategic Alliances at Enamine, added: “After 13 months of the war in the country, we are especially pleased to announce our collaboration with Endogena, a longlasting partner we have been serving during those several years with extensive medicinal chemistry and SAR efforts”.

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N-Nitrosamines as Cancerogenic Impurities

Since 2018, several drugs have been recalled from the market following the discovery of N-nitrosamine impurities in their commercial batches. The N-nitrosamines have been linked to an elevated risk of several cancers especially in case of continuous intake. Since 2020, the FDA and other authorities worldwide have mandated control of N-nitrosamine levels in commercial drugs.

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Mechanism

N-nitrosamines can form as impurities in the process of chemical drug production. Following the drug administration, oxidation of the N-nitrosamine species by cytochrome P450 leads to downstream production of cancerogenic diazonium salts that damage DNA by alkylation of susceptible nucleobases. Acceptable daily intake limits have been mandated by authorities for a large panel of N-nitrosamine species, which is, however, not explicit.

We offer

More than 200 N-nitrosamines from stock on a 5-10 g scale.

Saturated bioisosteres of meta-substituted benzene

Saturated bioisosteres of meta-substituted benzene offer several advantages in drug design and medicinal chemistry. They can enhance the metabolic stability of a molecule, improving its bioavailability. These bioisosteres also allow for the modulation of a molecule's lipophilicity, optimizing its solubility and permeability properties. Additionally, they can alter the interaction of a molecule with its target receptor, improving potency and specificity. The use of bioisosteres can provide opportunities for intellectual property protection by creating novel chemical entities. Enamine offers a variety of saturated bioisosteres of meta-substituted benzene.

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Design

We offer

More than 100 bioisosteres from stock on a 5-10 g scale.

Fluorinated Benzodioxoles

Drugs with the benzodioxole moiety showed excellent bioavailability and low cytotoxicity. The benzodioxole structure inspired the creation of fluorinated analogues to improve drug-target interactions and metabolic stability. Lumacaftor and Tezacaftor represent an innovative type of drugs: the small molecule chaperones. The difluoro-1,3-benzodioxol-5-yl-cyclopropane carboxamide group, shared between both drugs, binds to the nascent chain of the mutant protein during its biosynthesis. In this way, the protein corrects the folding defects and escapes premature degradation that could cause disease. Enamine offers a variety of advanced building blocks that share the fluorinated benzodioxole core structure.

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Concept

We offer

More than 100 fluorinated benzodioxoles and analogues from stock on a 5-10 g scale.

Bioisosteres of tert-butyl group

The tert-butyl group (-C(CH3)3) is a common motif in drug design due to its steric and electronic properties. Its bulky size and non-polar nature can be mimicked by other groups. Examples of bioisosteres of the tert-butyl group include cyclopropyl, cyclobutyl, isopropyl, and fluorine. These compounds can be used to modify the lipophilicity, solubility, and pharmacokinetic properties of a drug molecule to improve its efficacy and safety.

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Concept

We offer

More than 100 bioisosteres of tert-butyl group from stock on a 5-10 g scale.

Non-traditional fluoroalkyl groups

A wide variety of fluoroaliphatic moieties remain severely underexplored in drug design, in contrast to the CF3-group, which is among the most frequently found fragments in modern pharmaceuticals. In recent years, a growing set of examples have demonstrated a considerable potential of variable non-traditional fluoroalkyl groups in both, medicinal chemistry and agrochemical fields. These structures may address the issues associated with lipophilicity profile and metabolic degradation schemes of biologically active molecules.

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Concept

We offer

More than 100 non-traditional fluoroaliphatic compounds from stock on a 5-10 g scale.

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